There have been rare reports of prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) for this class of compounds, including vardenafil. In the event that an erection persists longer than 4 hours, the patient should seek immediate medical assistance. If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result. Concomitant administration with strong CYP3A4 inhibitors (such as ritonavir, indinavir, cobicistat, ketoconazole) or moderate CYP3A4 inhibitors (such as erythromycin) increases plasma concentrations of vardenafil.

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It must not be used when sexual activity is inadvisable, such as in men with severe heart disease. It must also not be used in patients who have ever had loss of vision because of a problem with blood flow to the nerve in the eye (non?arteritic anterior ischemic optic neuropathy or NAION). cheap levitra uk comment here must not be taken with nitrates (medicines used to treat angina). Vardenafil increases heart rate and also exaggerates blood pressure lowering effects of nitrates (for example, nitroglycerine).
Levitra can be taken with or without food, but high-fat meals may delay its onset of action. Many supplements and alternative therapies are marketed with claims to help men with ED. The U.S. Food and Drug Administration (FDA) warns that these products may contain potentially harmful drugs, contaminated formulations, or unknown dosages of pharmacologically active medications. It’s important to tell your doctor about all the drugs you take, including nonprescription ones, so they can determine if any of your medications could be responsible for your symptoms.
Contact your care team right away if the erection lasts longer than 4 hours or if it becomes painful. This may be a sign of serious problem and must be treated right away to prevent permanent damage. It works by increasing blood flow to the penis, which helps to maintain an erection.

Side Effects

If there is no response or side effects, the dose may be increased to 20 mg or, if there are side effects, it may be reduced to 5 mg. Vardenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, vardenafil works by increasing blood flow to the penis to help a man get and keep an erection. Levitra (vardenafil hydrochloride) is an oral medication taken to treat erectile dysfunction (ED). It’s in the same class of drugs as other popular ED medications, including buy viagra professional online how to buy online and Cialis.
The interaction is a consequence of blocking hepatic metabolism of vardenafil by ritonavir, a HIV protease inhibitor and a highly strong CYP3A4 inhibitor, which also inhibits CYP2C9. Consequently, it is recommended not to exceed a single 2.5 mg LEVITRA dose in a 72-hour period when used in combination with ritonavir. [see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS]. The recommended starting dose of Levitra is 10 mg, taken orally, as needed, approximately 60 minutes before sexual activity.
Therefore, patients are advised to take Levitra on an empty stomach or with a light meal to ensure optimal pharmacokinetic performance. Medicines are sometimes prescribed for conditions other than those described in patient information leaflets. Do not use LEVITRA for a condition for which it was not prescribed. Do not give LEVITRA to other people, even if they have the same symptoms that you have.

Nifedipine did not alter the plasma levels of Levitra when taken in combination. In these patients whose hypertension was controlled with nifedipine, Levitra 20 mg produced mean additional supine systolic/diastolic blood pressure reductions of 6/5 mmHg compared to placebo. Ritonavir (600 mg b.i.d.) co-administered with Levitra 5 mg resulted in a 49-fold increase in vardenafil AUC and a 13fold increase in vardenafil Cmax.
Levitra was administered to over 4430 men (mean age 56, range years; 81% White, 6% Black, 2% Asian, 2% Hispanic and 9% Other) during controlled and uncontrolled clinical trials worldwide. Over 2200 patients were treated for 6 months or longer and 880 patients were treated for at least 1 year. A starting dose of 5 mg should be considered for patients with mild and moderate liver problems or severe kidney problems.